Current Issue : July-September Volume : 2019 Issue Number : 3 Articles : 3 Articles
Wound healing is a normal biological process which is achieved through four indeed and highly involuntary phases: hemostasis, inflammation, proliferation and remodeling. All four phases must be happened in the appropriate sequence and time frame work to heal a wound successfully. Nanotechnology has appeared as a major platform to treat acute and chronic wounds. Various nanotechnology based drug delivery systems represents multiple functions and unique possessions associated with mechanism of wound healing. Gold, silver and copper nanoparticles and zinc oxide nanoparticles have shown impending therapeutic effects on wound healing. Nanoparticles such as nanocapsules, solid lipid nanoparticles and polymeric nanocomplexes are ideal vehicles to improve the effect of drugs (antibiotics, growth factors, etc.) in wound healing due to their specific characteristics. In this review, discussed on the significant findings in the area of nanoparticles in wound treatments....
In the modern-day global, a number of therapeutic proteins which includes vaccines, antigens and hormones are being advanced using one-of-a-kind sophisticated biotechnological strategies like Recombinant DNA technology and protein purification. However, the predominant glitches inside the foremost utilization of therapeutic proteins and peptides by way of the oral path are their large hepatic first-pass metabolism, degradation inside the gastrointestinal tract due to enzymes and pH-dependent factors, large molecular size and poor permeation. These problems can be overcome by adopting strategies consisting of chemical transformation of protein structures, enzyme inhibitors, mucoadhesive polymers and permeation enhancers. Being invasive, parenteral route is inconvenient for the administration of protein and peptides, numerous research endeavours have been undertaken to formulate a better delivery system for proteins and peptides with major emphasis on non-invasive routes along with oral, transdermal, vaginal, rectal, pulmonary and intrauterine. This overview article emphasizes on the latest improvements made inside the delivery of protein and peptides through a non-invasive (peroral) route into the body....
Research concept was to emphasize mainly on the merits of MDT as it counteracts the demerits of other conventional dosage form, i.e. dysphagia. MDT is a dosage form which disintegrates instantly when placed on tongue, releases the medicament that dissolves/disperses in the saliva. Telmisartan which is a BCS class II anti-hypertensive drug is framed into its sodium salt form, increasing its solubility. The disintegration time is less than 30 seconds and the enhanced solubility makes an attribute that makes this dosage form attractive to the patients. Thus, there is a dual benefit of enhanced solubility as well as benefit of the dosage form. The aim was to formulate MDT highlighting the use of super-disintegrating agents and taste masking agents in formulation by direct compression. Four superdisintegrants were tested, they were sodium starch glycolate (SSG), croscarmellose sodium (CCS), crospovidone (CP) and kyron T-314. The results showed that, formulation PF8 containing crospovidone gave better results compared to other superdisintegrants. Then the formulation PF8 was optimized using Design expert 7.0 by 32 factorial method. From the factorial formulations, FF5 containing silicified microcrystalline cellulose (SMCC, 18.75%) and crospovidone (5%) gave satisfactory results....
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